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July 31, 2025Obesity Reviews

Association of Childhood Obesity Phenotypes With Cardiometabolic Outcomes in Adulthood: A Systematic Review and Meta‐Analysis

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Authors

JHJia‐Shuan HuangXZXuanyu ZhangRRRema Ramakrishnan

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Overview

Systematic review shows children with metabolically unhealthy obesity face greater diabetes risk in adulthood, suggesting monitoring is essential.

Key Points

  • Children with metabolically healthy obesity (MHO) have a 2.72 times higher risk of diabetes compared to metabolically healthy normal weight (MHNW).
  • Metabolically unhealthy obesity (MUO) participants showed a 3.94 times greater risk of diabetes than MHNW.
  • Long-term risks of diabetes and metabolic syndrome decreased with adult BMI adjustments, especially for MHO.
  • Regular monitoring and timely interventions are vital for children with MUO to reduce future health risks.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c5fe6551bb0af8cf59ehttps://doi.org/10.1111/obr.70006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relation of Childhood Obesity/Cardiometabolic Phenotypes to Adult Cardiometabolic Profile: The Bogalusa Heart Study2012 · 122 citations
  2. 2Youth Overweight and Metabolic Disturbances in Predicting Carotid Intima-Media Thickness, Type 2 Diabetes, and Metabolic Syndrome in Adulthood: The Cardiovascular Risk in Young Finns Study2014 · 74 citations
  3. 3Weight change from childhood to adulthood and cardiovascular risk factors and outcomes in adulthood: A systematic review of the literature2020 · 57 citations
  4. 4Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults2024 · 2,415 citations
  5. 5Metabolically healthy overweight/obesity are associated with increased risk of cardiovascular disease in adults, even in the absence of metabolic risk factors: A systematic review and meta‐analysis of prospective cohort studies2020 · 139 citations