Key result
Factor V-Leiden links to DVT in both populations but prothrombin G20210A only in Lebanese patients.
Why the study?
The contribution of factor V-Leiden and prothrombin G20210A polymorphisms to deep venous thrombosis susceptibility among Lebanese and Tunisian patients was unclear.
Are Factor V-Leiden and prothrombin G20210A mutations associated with deep venous thrombosis in Lebanese and Tunisian populations?
Case-Control (n=1,061)
Yes
Are Factor V-Leiden and prothrombin G20210A mutations associated with deep venous thrombosis in Lebanese and Tunisian populations?
p-value: p=<0.001
The genetic susceptibility to DVT conferred by the prothrombin G20210A mutation varies between Lebanese and Tunisian populations, highlighting regional differences in prothrombotic genetic risk factors.
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May inform ethnicity-specific DVT risk assessment in Middle Eastern/North African patients; leaves open need for prospective validation of these associations.
Bouaziz-Borgi et al. (2006) conducted a case-control in Deep venous thrombosis (n=1,061). Factor V-Leiden and prothrombin G20210A mutations vs. Healthy controls was evaluated on Deep venous thrombosis (p=<0.001). Factor V-Leiden was associated with deep venous thrombosis in both populations, while the prothrombin G20210A mutation was significantly associated with DVT only in Lebanese patients (P<0.001).
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