Key result
DKA treatment links to ~9% narrower lateral ventricles versus recovery, associated with lower initial PCO2.
Why the study?
The frequency of asymptomatic or subclinical cerebral edema in children with diabetic ketoacidosis is uncertain, with conflicting evidence on ventricular narrowing.
Does sub-clinical cerebral edema (ventricular narrowing) occur frequently in children during treatment for diabetic ketoacidosis?
Comparison
MRI during DKA treatment vs MRI after recovery from DKA
Design
Observational cohort study
Follow-up
After recovery from DKA episode
Authors
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May indicate frequent sub-clinical cerebral edema in pediatric DKA; hypothesis-generating and should not yet change practice.
Observational (n=41)
Does sub-clinical cerebral edema (ventricular narrowing) occur frequently in children during treatment for diabetic ketoacidosis?
Absolute Event Rate: 9.3% vs 10.2%
p-value: p=<0.001
Sub-clinical cerebral edema, evidenced by ventricular narrowing on MRI, occurs in over half of children treated for DKA and is associated with mild mental status abnormalities.
Glaser et al. (2006) conducted an observational in Diabetic ketoacidosis (n=41). Diabetic ketoacidosis treatment phase vs. After recovery from diabetic ketoacidosis was evaluated on Intercaudate width of the frontal horns of the lateral ventricles (mm) (p=<0.001). Lateral ventricles were significantly smaller during diabetic ketoacidosis treatment than after recovery (9.3 vs. 10.2 mm, p<0.001), and narrowing was associated with lower initial PCO2.
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