Key result
Noninvasive His-Purkinje ECG strongly correlates with invasive H-V time in patients with long P-R intervals.
Why the study?
A noninvasive method to record electrical activity of the His-Purkinje system in humans was needed to assess its uses and limitations.
Does noninvasive recording of His-Purkinje electrical activity correlate with invasive H-V time measurements in patients?
Observational
Does noninvasive recording of His-Purkinje electrical activity correlate with invasive H-V time measurements in patients?
Noninvasive recording of His-Purkinje electrical activity using signal averaging strongly correlates with invasive H-V time measurements, offering a potential noninvasive diagnostic tool.
Noninvasive His-Purkinje recording may aid conduction assessment; leaves open validation, standardization, and outcome correlation before clinical adoption.
A methodology is described for noninvasive recording of the electrical activity generated by the His-Purkinje system of man utilizing filtering, high amplification, and signal averaging. A waveform ranging between 1 and 10mu V was observed during the P-R segment. In many individuals, there was temporal overlap between the terminal P wave and the initial portion of the His-Purkinje waveform. In ten patients with long P-R intervals there was a strong correlation (r greater than 0.95) between the H-V time measured by electrode catheter and the duration of the His-Purkinje waveform. In two patients with atrial fibrillation the resultant His-Purkinje waveform was similar in morphology and duration to those observed in the ten patients. In each group H-V time was determined noninvasively and a waveform associated with electrical activation of the major portions of the His-Purkinje system was obtained.
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Berbari et al. (1976) conducted an observational in Long P-R intervals or atrial fibrillation. Noninvasive His-Purkinje electrocardiogram vs. Electrode catheter was evaluated on Correlation between noninvasive and catheter-measured H-V time (r > 0.95). Noninvasive recording of the His-Purkinje electrocardiogram strongly correlated (r > 0.95) with H-V time measured by electrode catheter in patients with long P-R intervals.
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