Key result
Cyclosporine therapy is linked to higher plasma endothelin levels.
Why the study?
The mechanism by which cyclosporine induces acute renal vasoconstriction remains unclear, with endothelin suggested as a potential mediator.
Does cyclosporine therapy increase plasma endothelin concentrations?
Does cyclosporine therapy increase plasma endothelin concentrations?
This letter investigates the effect of cyclosporine on plasma endothelin levels to explore its role in acute renal vasoconstriction.
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Cyclosporine-associated endothelin elevation may contribute to renal vasoconstriction; leaves open causal confirmation in larger studies.
Deray et al. (1991) conducted a letter in Cyclosporine therapy (n=14). Cyclosporine was evaluated on Plasma endothelin concentrations. Cyclosporine therapy was associated with increased plasma endothelin levels in 14 treated patients, though specific quantitative results were not reported in the truncated abstract.
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