Why the study?
Does the ETA receptor antagonist FR 139317 prevent cyclosporine-induced hypertension in rats?
Population
Wistar-Kyoto rats treated with cyclosporine (25 mg/kg per day) for 4 weeks to induce hypertension
Comparison
Endothelin type A receptor antagonist FR 139317… vs Cyclosporine alone (25 mg/kg per day)
Design
Preclinical
Follow-up
4 weeks
Authors
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May implicate ETA receptors in cyclosporine hypertension; leaves open clinical translation in humans.
Does the ETA receptor antagonist FR 139317 prevent cyclosporine-induced hypertension in rats?
The ETA receptor antagonist FR 139317 blunts cyclosporine-induced hypertension in rats, suggesting a role for ETA receptors in this pathology.
Takeda et al. (1995) studied this question.
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