Key result
Periodontal disease severity is linked to lower gingival crevicular fluid periostin levels versus healthy controls.
Why the study?
Periostin is essential for periodontal tissue integrity, but its levels in gingival crevicular fluid and serum in periodontal disease patients compared to healthy individuals were not well characterized.
Cross-Sectional (n=80)
p-value: p=<0.05
Periostin levels in gingival crevicular fluid decrease with the progression of periodontal disease and may serve as a reliable marker for disease susceptibility and activity.
Lower periostin in GCF may indicate periodontal activity; leaves open its role as a biomarker pending longitudinal validation.
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Ballı et al. (2014) conducted a cross-sectional in Periodontal disease (n=80). Periodontal disease severity vs. Periodontal-healthy group was evaluated on Periostin levels in gingival crevicular fluid and serum (p=<0.05). Periodontal disease progression and severity was associated with significantly decreased periostin levels in gingival crevicular fluid compared to healthy controls (p < 0.05).
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