Key result
Targeted medical therapy successfully reverses impaired platelet activation following a 12 g dipyridamole overdose.
Why the study?
Toxicokinetic data and corresponding pharmacodynamic effects after dipyridamole intoxication were previously unreported.
Case Report (n=1)
This is the first report providing toxicokinetic data and corresponding pharmacodynamic effects (impaired platelet activation) following dipyridamole intoxication.
Massive dipyridamole ingestion may cause reversible platelet dysfunction responsive to supportive care; leaves open optimal toxicity thresholds and management strategies.
We report a case of a 51-year-old woman who was admitted to the hospital after ingestion of large doses of dipyridamole (12 g), temazepam (1 g) and oxazepam (0.2 g) with suicidal intent. The highest dipyridamole concentration that was measured in serum was 9.2 mg/L, which was paralleled by impaired platelet activation. For temazepam and oxazepam, peak serum concentrations were 8.5 and 1.3 mg/L, respectively. The patient was treated with activated charcoal, magnesium sulfate and aminophylline and could be discharged in good physical condition within 17 hours. This is the first report that provides toxicokinetic data and a corresponding pharmacodynamic effect after an intoxication with dipyridamole.
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Lagas et al. (2010) conducted a case report in Dipyridamole intoxication (n=1). Dipyridamole intoxication was evaluated on Toxicokinetic data and pharmacodynamic effect (impaired platelet activation). Ingestion of 12 g of dipyridamole resulted in a peak serum concentration of 9.2 mg/L and impaired platelet activation, which was successfully treated and the patient discharged within 17 hours.
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