Key result
Intramyocellular lipid accumulation correlates with greater visceral fat and higher TG/HDL ratios in children.
Why the study?
Relatively little is known about intramyocellular lipid deposition and its relationship with visceral adiposity, insulin resistance, and cardiovascular risk before puberty.
Is intramyocellular lipid accumulation associated with visceral adiposity and markers of cardiovascular risk in prepubertal and early pubertal children?
Population
441 prepubertal and early pubertal children
Comparison
Intramyocellular lipid levels in relation to visceral adiposity and metabolic markers
Design
Retrospective cohort study
Authors
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May signal early cardiometabolic vulnerability in children; hypothesis-generating and should not yet change practice.
Cohort (n=441)
Is intramyocellular lipid accumulation associated with visceral adiposity and markers of cardiovascular risk in prepubertal and early pubertal children?
Effect estimate: parameter estimate 0.019 for visceral fat; 0.1418 for TG/HDL ratio
p-value: p=0.002
Intramyocellular lipid accumulation is associated with visceral adiposity and markers of cardiovascular risk in prepubertal children, independent of overall adiposity.
Brumbaugh et al. (2012) conducted a cohort in Metabolic dysregulation and cardiovascular risk (n=441). Intramyocellular lipid (IMCL) accumulation was evaluated on Visceral adiposity and triglyceride to high-density lipoprotein ratio (parameter estimate 0.019 for visceral fat; 0.1418 for TG/HDL ratio, p=0.002). Intramyocellular lipid accumulation was significantly associated with visceral fat in prepubertal children (P=0.002) and the triglyceride to high-density lipoprotein ratio in all children (P=0.002).
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