New Selenium-Based Safety-Catch Linkers: Solid-Phase Semisynthesis of Vancomycin

Pro-allyl and pro-alloc linkers can be formed by alkylation or esterification of a selenium-bound resin (the example shown is for the formation of a polymer-bound pro-allyl derivative) and can be readily cleaved in excellent yields under mild conditions. The scope of the pro-allyl linker has been demonstrated with the solid-phase semisynthesis of vancomycin. Alloc=allyloxycarbonyl.