Key result
Borderline essential hypertension links to altered leucocyte migration, suggesting delayed hypersensitivity to arterial wall components.
Why the study?
Delayed hypersensitivity against arterial wall components may be a pathogenetic factor in patients with borderline essential hypertension, but this has not been demonstrated.
Is delayed hypersensitivity against arterial wall components increased in patients with borderline essential hypertension compared to normal persons?
Case-Control (n=38)
Is delayed hypersensitivity against arterial wall components increased in patients with borderline essential hypertension compared to normal persons?
Delayed hypersensitivity against arterial wall components may be a pathogenetic factor in essential hypertension.
Answers are grounded in this paper and cite their sources.
May indicate immunologic role in borderline hypertension; hypothesis-generating and should not yet change practice.
By means of the leucocyte migration technique, it has been demonstrated that the migration indices from 19 patients suffering from borderline essential hypertension are significantly different from those of 19 normal persons. These results support the view that delayed hypersensitivity directed against arterial wall components is a possible pathogenetic factor in patients suffering from essential hypertension.
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Olsen et al. (1977) conducted a case-control in Borderline essential hypertension (n=38). Borderline essential hypertension vs. Normal persons was evaluated on Leucocyte migration indices. Patients with borderline essential hypertension had significantly different leucocyte migration indices compared to normal persons, suggesting delayed hypersensitivity to arterial wall components.
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