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March 1, 1991Diabetes Care

Borderline hypertension is characterized by neurogenic elevated cardiac output and normal vascular resistance, which transitions to high-resistance established hypertension due to vascular hypertrophy and decreased cardiac responsiveness.

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Population

Patients with borderline and established essential hypertension

Design

Review

Authors

SJStevo Julius

Discussion

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Overview

Suggests sympathetic modulation as potential early target; leaves open whether intervention alters progression in prospective trials.

Structured PICO

P
Population
Patients with borderline and established essential hypertension

This review highlights the central role of increased sympathetic drive in the pathophysiology of borderline hypertension and its transition to established hypertension, as well as its association with metabolic abnormalities.

Cite This Study

Stevo Julius (1991) studied this question.

synapsesocial.com/papers/6a70bf8f87f921057127dd27https://doi.org/10.2337/diacare.14.3.249
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