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March 1, 1971CirculationOpen Access

Relationship Between Cardiac Output and Peripheral Resistance in Borderline Hypertension

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Why the study?

What is the relationship between cardiac output and peripheral resistance in patients with borderline hypertension compared to healthy controls under various hemodynamic conditions?

Population

77 patients with borderline hypertension and 82 healthy control subjects

Comparison

Hemodynamic evaluation under various conditions vs Healthy control subjects

Design

Cross-sectional

Authors

SJStevo JuliusRSR SannerstedtCMCharles Mitchell

Discussion

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Overview

Suggests multifactorial hemodynamics in borderline hypertension; hypothesis-generating for progression mechanisms in longitudinal studies.

Structured PICO

What is the relationship between cardiac output and peripheral resistance in patients with borderline hypertension compared to healthy controls under various hemodynamic conditions?

P
Population
77 patients with borderline hypertension and 82 healthy control subjects
I
Intervention
Hemodynamic evaluation under various conditions (assumption of the sitting position, mild exercise, infusion of dextran, blockade with propranolol, and combination of propranolol and atropine)
C
Comparator
Healthy control subjects
O
Outcome
Cardiac output, peripheral resistance, and blood pressuresurrogate

Borderline hypertension is not caused solely by elevations of cardiac output, as blood pressure remains elevated even when cardiac output is reduced and peripheral resistance is increased.

Cite This Study

Julius et al. (1971) studied this question.

synapsesocial.com/papers/6a8843e5ab77196d53aa73c8https://doi.org/10.1161/01.cir.43.3.382
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemodynamic Studies in Patients with Borderline Blood Pressure Elevation1968 · 237 citations
  2. 2Borderline Hypertension : Correlation Between the Cardiac Output and the Vascular Reactivity to Norepinephrine1974
  3. 3Role of Parasympathetic Inhibition in the Hyperkinetic Type of Borderline Hypertension1971 · 339 citations
  4. 4Autonomic Nervous Dysfunction in Essential Hypertension1991 · 40 citations
  5. 5Hemodynamic Responses to Tilt and Beta-Adrenergic Blockade in Young Patients with Borderline Hypertension1970 · 65 citations