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January 1, 1974Acta Clinica Belgica

The pressor dose of norepinephrine was significantly increased (P <0.001) in borderline hypertensives and was directly correlated with cardiac output (P <0.001).

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Why the study?

Does vascular reactivity to norepinephrine correlate with cardiac output in borderline hypertensive patients compared to normal subjects?

Population

24 borderline hypertensive patients and 12 normal subjects (total n=36)

Comparison

Assessment of haemodynamic parameters and… vs 12 normal subjects

Design

Case-control

Authors

MSMichel E. SafarGLGérard M. LondonYWY Weiss

Discussion

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Overview

Suggests possible adrenergic role in borderline hypertension; hypothesis-generating and should not change practice.

Structured PICO

Does vascular reactivity to norepinephrine correlate with cardiac output in borderline hypertensive patients compared to normal subjects?

P
Population
24 borderline hypertensive patients and 12 normal subjects (total n=36)
I
Intervention
Assessment of haemodynamic parameters and vascular reactivity to norepinephrine, angiotensin, and isoproterenol
C
Comparator
12 normal subjects
O
Outcome
Haemodynamic parameters (blood pressure, cardiac index, heart rate, total peripheral resistance) and vascular reactivity to norepinephrinesurrogate

In borderline hypertension, increased vascular reactivity to norepinephrine correlates with cardiac output, suggesting a role for the adrenergic system.

Cite This Study

Safar et al. (1974) studied this question.

synapsesocial.com/papers/6a72ae6ace524a4339c5886ehttps://doi.org/10.1080/17843286.1974.11716947
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