Why the study?
Does vascular reactivity to norepinephrine correlate with cardiac output in borderline hypertensive patients compared to normal subjects?
Does vascular reactivity to norepinephrine correlate with cardiac output in borderline hypertensive patients compared to normal subjects?
In borderline hypertension, increased vascular reactivity to norepinephrine correlates with cardiac output, suggesting a role for the adrenergic system.
Answers are grounded in this paper and cite their sources.
Suggests possible adrenergic role in borderline hypertension; hypothesis-generating and should not change practice.
SummaryHaemodynamic parameters and vascular reactivity to norepinephrine were determined in 24 borderline hypertensive patients in comparaison with 12 normal subjects. Borderline hypertensives had high values of blood pressure (P < 0.001), cardiac index (P <0.01) and heart rate (P <0.05) and normal values of total peripheral resistance. The pressor dose of norepinephrine was significantly increased (P <0.001) and was directly correlated with the cardiac output (P <0.001). This result was not observed with the angiotensin and isoproterenol and could suggest the role of the adrenergic system in borderline hypertension.
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Safar et al. (1974) studied this question.
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