Key result
Noise-induced stochastic alternations drive synchronized EAD-like rhythms in cultured cardiac myocytes.
Why the study?
Synchronous early after-depolarization-like rhythms in cultured cardiac myocytes and their underlying mechanisms were not fully understood.
Answers are grounded in this paper and cite their sources.
Dissolved cardiac myocytes can couple together and generate synchronous beatings in culture. We observed a synchronized early after-depolarization(EAD)-like rhythm in cultured cardiac myocytes and reproduced the experimental observation in a network mathematical model whose dynamics are close to a Hopf bifurcation. The mechanism for this EAD-like rhythm is attributed to noised-induced stochastic alternatings between the focus and the limit cycle. These results provide novel understandings for pathological heart rhythms like the early immature beatings.
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Zhang et al. (2009) studied Early after-depolarization (EAD)-like rhythm. Cultured cardiac myocytes and network mathematical modeling was evaluated on Synchronized early after-depolarization (EAD)-like rhythm. Synchronized early after-depolarization (EAD)-like rhythms in cultured cardiac myocytes are driven by noise-induced stochastic alternatings between the focus and the limit cycle.
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