Key result
Desipramine is linked to a fourth pediatric sudden death, potentially driven by long QT syndrome.
Why the study?
Considerable uncertainty remains about the basis of the apparent association between desipramine use and sudden death in children with behavioral disorders.
Does desipramine cause sudden death in children?
Design
Case report
Authors
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Should not yet change desipramine prescribing in children; hypothesis-generating for long QT-mediated sudden death.
Case Report (n=4)
Does desipramine cause sudden death in children?
This case series highlights a potential association between desipramine use in children and sudden death, possibly mediated by long QT syndrome.
Riddle et al. (1993) conducted a case report in Behavioral disorders (n=4). Desipramine was evaluated on Sudden death. Desipramine use in children for behavioral disorders was associated with a fourth reported case of sudden death, with cardiac long QT syndrome proposed as a potential mechanism.
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