Key result
Administration of increasing doses of the tricyclic antidepressant desipramine induced prominent Brugada waves in a patient, suggesting a potential mechanism for sudden death risk with these drugs.
Why the study?
Does desipramine administration induce Brugada waves?
Case Report (n=1)
Does desipramine administration induce Brugada waves?
Tricyclic antidepressants like desipramine can induce Brugada waves, warranting careful ECG monitoring in cardiac and elderly patients.
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Desipramine was associated with Brugada waves in one case; hypothesis-generating for sudden death risk mechanism, requiring confirmation before clinical implications.
Babliaros et al. (2002) conducted a case report in Brugada syndrome (n=1). Desipramine (tricyclic antidepressant) was evaluated on Development of Brugada waves. Administration of increasing doses of the tricyclic antidepressant desipramine induced prominent Brugada waves in a patient, suggesting a potential mechanism for sudden death risk with these drugs.
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