Population
Isolated coronary-perfused canine right ventricular wedge preparations and isolated canine ventricular…
Design
Preclinical
Authors
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Amitriptyline may unmask Brugada phenotype via INa inhibition in Ito-augmented models; leaves open clinical translation and patient risk.
Amitriptyline unmasks the Brugada ECG phenotype and facilitates arrhythmogenesis by inhibiting sodium channel current in the setting of a genetic predisposition (simulated by increased Ito).
Minoura et al. (2011) studied this question.
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