Key result
Continuous sodium bicarbonate infusion led to the resolution of Brugada electrocardiographic pattern in a patient with amitriptyline overdose.
Case Report (n=1)
Continuous sodium bicarbonate infusion can successfully resolve Brugada electrocardiographic pattern induced by amitriptyline overdose.
Tricyclic antidepressants (TCAs) remain a common cause of fatal drug poisoning as a result of their cardiovascular toxicity manifested by electrocardiographic abnormalities, arrhythmias, and hypotension. The principal mechanism of toxicity is cardiac sodium channel blockade. Brugada electrocardiographic pattern (BEP) has also been described in TCA overdose. Currently, very little is known about the relationship between the Brugada syndrome and TCAs. We report the case of a patient who presented with BEP after intake of a high dose of amitriptyline. The patient was treated with continuous sodium bicarbonate infusion leading to resolution of BEP.
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Palaniswamy et al. (2010) conducted a case report in Amitriptyline overdose with Brugada electrocardiographic pattern (n=1). Continuous sodium bicarbonate infusion was evaluated on Resolution of Brugada electrocardiographic pattern. Continuous sodium bicarbonate infusion led to the resolution of Brugada electrocardiographic pattern in a patient with amitriptyline overdose.
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