Key result
Therapeutic-dose amitriptyline was associated with ventricular tachycardia and a Type 1 Brugada electrocardiogram pattern in a 32-year-old woman with anorexia nervosa.
Why the study?
Does high-dose amitriptyline cause ventricular tachycardia and Brugada pattern in patients with low body weight?
Case Report (n=1)
Does high-dose amitriptyline cause ventricular tachycardia and Brugada pattern in patients with low body weight?
High-dose amitriptyline can induce a Type 1 Brugada pattern and ventricular tachycardia, particularly in patients with low body weight, necessitating careful ECG monitoring.
Therapeutic amitriptyline may induce Brugada pattern and VT in low-body-weight patients; leaves open need for ECG monitoring protocols.
A 32-year-old woman with anorexia nervosa experienced ventricular tachycardia while on therapeutic-dose amitriptyline despite normal blood tests, imaging, and intracardiac recordings. Electrocardiograms over several years featured the Type 1 Brugada pattern. Careful electrocardiogram monitoring should be made if using high doses of amitriptyline, especially in those with low body weight. (Level of Difficulty: Intermediate.)
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Chow et al. (2021) conducted a case report in Anorexia nervosa, ventricular tachycardia, Brugada Type 1 pattern (n=1). Amitriptyline was evaluated on Ventricular tachycardia and Type 1 Brugada pattern. Therapeutic-dose amitriptyline was associated with ventricular tachycardia and a Type 1 Brugada electrocardiogram pattern in a 32-year-old woman with anorexia nervosa.
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