Key result
Running increases LV mass ~2.5-fold more in female than male mice, linked to fatty acid utilization.
Why the study?
Sex-specific regulation of exercise-induced cardiac hypertrophy and its association with differences in cardiac energy substrate availability and utilization were not fully understood.
Population
Female and male C57BL/6J mice
Comparison
Active treadmill running vs sedentary
Design
Preclinical study with cardiac and metabolic phenotyping
Follow-up
4 weeks
Authors
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Does not inform human exercise prescriptions; leaves open whether sex differences in cardiac remodeling extend to patients.
Absolute Event Rate: 22.2% vs 9%
p-value: p=< 0.05
Sex differences in exercise-induced cardiac hypertrophy in mice are associated with changes in cardiac substrate availability and utilization, with females showing greater hypertrophy and preferential fatty acid utilization.
Foryst‐Ludwig et al. (2011) studied Exercise-induced cardiac hypertrophy. Active treadmill running vs. Male mice was evaluated on Percent increase in left ventricular mass (LVM) (p=< 0.05). Active treadmill running for 4 weeks induced a greater increase in left ventricular mass in female mice compared with male mice (22.2% vs 9.0%; P<0.05), linked to higher fatty acid utilization.
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