Key result
High-intensity exercise shifts the cardiac metabolome more in female mice than males without affecting mitochondrial respiration.
Why the study?
Although structural and functional cardiac effects of exercise are well established, metabolic changes occurring in the heart during and after exercise remain unclear.
Population
Male and female mice
Comparison
1 session of treadmill exercise vs sedentary state across exercise intensities
Design
Preclinical animal metabolomics study
Follow-up
1 h after the exercise session
Authors
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Sex-specific cardiac metabolic responses to acute exercise seen in mice; hypothesis-generating for human studies and should not yet inform practice.
This preclinical study demonstrates significant sex-dependent differences in basal cardiac metabolism and reveals that the female murine heart is metabolically more responsive to acute exercise stress.
Fulghum et al. (2022) studied Exercise-induced cardiac metabolic changes. Treadmill exercise vs. Sedentary control was evaluated on Changes in cardiac metabolome and mitochondrial respiration. A single bout of high-intensity treadmill exercise induced more extensive time-dependent changes in the cardiac metabolome of female mice compared to male mice, without acutely affecting mitochondrial respiration.
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