Key result
Acute high-intensity exercise alters myocardial and serum metabolism, identifying 12 markers across key metabolic pathways.
Why the study?
Few metabolomics-based studies have provided data on the effect of acute high-intensity exercise on myocardial metabolism.
Does acute high-intensity exercise alter metabolic signatures in rat myocardium and human serum?
Does acute high-intensity exercise alter metabolic signatures in rat myocardium and human serum?
Acute high-intensity exercise significantly alters myocardial metabolism, identifying specific metabolic pathways and markers that could aid in pre-competition screening and risk prevention.
Metabolic markers after intense exercise may signal myocardial stress; leaves open validation for injury prediction in athletes.
Acute high-intensity exercise can affect cardiac health by altering substance metabolism. However, few metabolomics-based studies provide data on the effect of exercise along with myocardial metabolism. Our study aimed to identify metabolic signatures in rat myocardium during acute high-intensity exercise and evaluate their diagnostic potential for sports injuries. We collected rat myocardium samples and subjects' serum samples before and after acute high-intensity exercise for metabolite profiling to explore metabolic alterations of exercise response in the myocardium. Multivariate analysis revealed myocardium metabolism differed before and after acute high-intensity exercise. Furthermore, 6 target metabolic pathways and 12 potential metabolic markers for acute high-intensity exercise were identified. Our findings provided an insight that myocardium metabolism during acute high-intensity exercise had distinct disorders in complex lipids and fatty acids. Moreover, an increase of purine degradation products, as well as signs of impaired glucose metabolism, were observed. Besides, amino acids were enhanced with a certain protective effect on the myocardium. In this study, we discovered how acute high-intensity exercise affected myocardial metabolism and exercise-related heart injury risks, which can provide references for pre-competition screening, risk prevention, and disease prognosis in competitive sports and effective formulation of exercise prescriptions for different people.
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Wu et al. (2022) studied Healthy (n=24). Acute high-intensity exercise vs. Pre-exercise baseline (humans) / Sedentary control (rats) was evaluated on Metabolic profile alterations. Acute high-intensity exercise significantly altered myocardial and serum metabolism, identifying 6 target metabolic pathways and 12 potential metabolic markers associated with lipid, glucose, and amino acid metabolism.
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