Key result
Long-term moderate exercise in male rats significantly decreased myocardial metabolites including bile acids, fatty acids, and phenylpropanoic acids, promoting lipid utilization.
Why the study?
The study aimed to investigate the effect of long-term moderate exercise on the myocardial metabolome in rats.
Does long-term moderate exercise alter the myocardial metabolome in rats?
RCT (n=13)
Randomly assigned
Does long-term moderate exercise alter the myocardial metabolome in rats?
Long-term moderate exercise alters the myocardial metabolome in rats, promoting lipid utilization and decreasing potentially detrimental metabolites like Neu5Ac, which may serve as a biomarker for cardioprotection.
Answers are grounded in this paper and cite their sources.
Animal metabolomics data suggest moderate exercise may protect myocardium; leaves open human translation and clinical relevance.
treadmill running) is optimal in protecting from exhaustive exercise-induced cardiac ischemic injury. This study is aimed to investigate the effect of long-term moderate exercise on myocardial metabolome in rats. Thirteen male Sprague-Dawley rats were randomly assigned into the control group (C) and the long-term moderate exercise group (E). The targeted metabolomics of the myocardium was analyzed by ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) system. Results showed that the metabolites categories of bile acids (BAs), fatty acids (FAs), and phenylpropanoic acids were significantly decreased. The biosynthesis of unsaturated FAs pathway was significantly downregulated. The altered metabolites in the E Group included decreased FAs (pentadecanoic acid, 10Z-heptadecenoic acid, dihomo-gamma-linolenic acid, docosahexaenoic acid, docosapentaenoic acid, and 10Z-nonadecenoic acid), decreased BAs (chenodeoxycholic acid and beta-muricholic acid), decreased organic acids (glycolic acid and 2-hydroxyglutaric acid), decreased carbohydrate (N-acetylneuraminic acid, Neu5Ac), decreased amino acids (α-aminobutyric acid and norvaline), decreased phenylpropanoic acids (hydroxyphenyllactic acid), and benzoic acids (4-hydroxybenzoic acid and phthalic acid). The results indicated that long-term moderate exercise has promoted lipids utilization in myocardium while exerted little influence on carbohydrate metabolism and diminished many detrimental metabolites. Notably, decrease of myocardial carbohydrate Neu5Ac after long-term moderate exercise might predict a prospective metabolomics biomarker for cardioprotection. This research has displayed the effect of long-term moderate exercise on myocardial metabolomic profiling in rats and indicated some promising metabolites which can be applied for exercise benefits in future.
No takes yet. Share an insight, caveat, or question.
Ping et al. (2023) reported an RCT. Long-term moderate exercise vs. Control was evaluated on Myocardial metabolome profiling. Long-term moderate exercise in male rats significantly decreased myocardial metabolites including bile acids, fatty acids, and phenylpropanoic acids, promoting lipid utilization.
Synapse has enriched 10 related papers. Consider them for comparative context: