Patient-Oriented Therapy with Nimesulide: Safety and Optimal Dosage Form

Nimesulide is a non-steroidal anti-infl ammatory drug.It is characterized by a predominant inhibition of cyclooxygenase-2 and the eff ect on the content of adenosine in the focus of infl ammation.In addition to inhibition of cyclooxygenase, nimesulide has a number of other eff ects.In particular, we are talking about the multidirectional eff ect on cell apoptosis.On the one hand, it is known its ability to inhibit apoptosis of chondrocytes, on the other -to accelerate the apoptosis of pancreatic cancer cells.Widely discussed its anti-ischemic eff ect on neurons, the ability to suppress the production of interleukin 6, and to have an anti-glycating eff ect.e advantages of the drug should also include relatively low risk of complications from the gastrointestinal tract and cardiovascular disasters.e dosage form is no less important.e convenient soluble form in the form of granules contributes not only to better bioavailability of nimesulide, but also to the increase of adherence of patients to treatment.e knowledge of the mechanism of the drug action, its pleiotropic eff ects, safety profi le, and features of diff erent dosage forms is necessary for the implementation of a patient-oriented approach to therapy.