Key result
COVID-19 recovery linked to dilated cardiomyopathy with biventricular and atrial thrombi, suggesting persistent coagulopathy.
Why the study?
COVID-19 can cause cardiovascular manifestations including myocardial injury and thromboembolic events, with complex coagulation abnormalities leading to a hypercoagulable state.
Case Report (n=1)
COVID-19 can cause delayed presentation of atrial and biventricular thrombi in patients with dilated cardiomyopathy, necessitating long-term cardiac monitoring.
May signal persistent thrombotic risk in post-COVID cardiomyopathy; hypothesis-generating and should not yet change practice.
Introduction: Coronavirus 2019 (COVID-19) can cause cardiovascular manifestations including myocardial injury and thromboembolic events. Case presentation: Here, we report a case of a 27-year-old female with dilated cardiomyopathy, right atrial and biventricular thrombi infected with COVID-19. Discussion: There are several complex coagulation abnormalities in COVID-19 patients that have been suggested to create a hypercoagulable state. Evidence have shown that endothelial injury potentially leading to thromboembolic events is caused by direct invasion of endothelial cell by SARS-CoV-2 and complement activation contributed by the virus spike protein. Conclusion: DCM can be complicated by atrial and biventricular thrombi due to coagulation abnormalities that are likely to persist after recovery from COVID-19. Thus, long-term careful monitoring of cardiac function is necessary after recovery of COVID-19.
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Shah et al. (2022) conducted a case report in COVID-19, dilated cardiomyopathy, atrial and biventricular thrombi (n=1). COVID-19 infection was evaluated. A 27-year-old female with COVID-19 presented with dilated cardiomyopathy complicated by right atrial and biventricular thrombi, suggesting persistent coagulation abnormalities after recovery.
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