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(±)-6-Methyl-6-azabicyclo[3.2.1]octan-3-one (1c) was prepared in three steps from 6-oxabicyclo[3.2.1]oct-3-en-7-one, and stereoselective reduction of (1c) provided (±)-6-methyl-6-azabicyclo[3.2.1]octan-3α-ol (1a); adaptation of the sequence provided the first synthesis of (+)- and (–)-(1a).
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Abraham et al. (1990) studied this question.
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