Key result
Cutaneous epithelioid angiosarcoma cases show a protracted course suggesting a better prognosis than suspected.
Why the study?
Some cutaneous epithelioid angiosarcomas are difficult to diagnose due to histological similarity to carcinomas and negative immunohistochemical markers, with uncertain prognosis.
Case Report (n=3)
Cutaneous epithelioid angiosarcomas with a solid pattern may have a more protracted course and better prognosis than previously thought, despite diagnostic challenges.
Answers are grounded in this paper and cite their sources.
May indicate prognostic variability in cutaneous epithelioid angiosarcoma; hypothesis-generating and should not yet change practice.
Three cases of cutaneous epithelioid angiosarcoma with solid pattern were studied by immunohistochemistry and electron microscopy. The neoplasms followed a slow, protracted course with local recurrences and regional lymph node metastases. The correct histological diagnosis was delayed by the close histological simulation of carcinomas, misleading ultrastructural findings, and largely negative immunohistochemical markers. Two of the patients have been followed for at least 48 months and are still alive. Some seemingly undifferentiated epithelioid angiosarcomas may entail a better prognosis than originally suspected.
No takes yet. Share an insight, caveat, or question.
Marrogi et al. (1990) conducted a case report in Cutaneous epithelioid angiosarcoma (n=3). Three cases of cutaneous epithelioid angiosarcoma followed a slow, protracted course, suggesting some seemingly undifferentiated epithelioid angiosarcomas may entail a better prognosis than suspected.
Synapse has enriched 10 related papers. Consider them for comparative context: