Key result
Higher IL-2R and VCAM-1 linked to increased carotid IMT in hemodialysis patients.
Why the study?
The excess risk for coronary heart disease in hemodialysis patients is not fully explained by traditional cardiovascular risk factors, prompting investigation of inflammatory markers' role in asymptomatic atherosclerosis.
Cross-Sectional (n=95)
Effect estimate: r = 0.269 (IL-2R), r = 0.290 (VCAM-1)
p-value: p=<0.022 (IL-2R), <0.014 (VCAM-1)
In hemodialysis patients, asymptomatic atherosclerosis measured by intima-media thickness correlates with non-traditional inflammatory risk factors such as IL-2R and VCAM-1.
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Bevc et al. (2008) conducted a cross-sectional in Hemodialysis (n=95). Inflammatory markers (hsCRP, IL-6, TNF-alpha, IL-2R, ICAM-1, VCAM-1) was evaluated on Correlation between intima-media thickness (IMT) values and serum concentrations of inflammatory markers (r = 0.269 (IL-2R), r = 0.290 (VCAM-1), p=<0.022 (IL-2R), <0.014 (VCAM-1)). Serum concentrations of inflammatory markers IL-2R and VCAM-1 correlated with carotid intima-media thickness in hemodialysis patients (r=0.269, p<0.022 and r=0.290, p<0.014, respectively).
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