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Demonstrates a novel synthetic route converting cardols from cashew nut shell liquid into lasiodiplodin, highlighting renewable feedstocks for bioactive macrolides.
As part of an ongoing program concerning utilisation of CNSL (Cashew Nut Shell Liquid) from Anacardium occidentale as starting material for the preparation of useful compounds, we describe the conversion of cardols (6-alkenylresorcinols) into lasiodiplodin, a naturally occurring 12-membered orsellinic acid type macrolide, which exhibits plant growth regulating and antileukemic properties.
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Santos et al. (1999) studied this question.
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