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October 1, 2004Journal of Clinical HypertensionOpen Access

Graded Blood Pressure Reduction in Hypertensive Outpatients Associated With Use of a Device to Assist With Slow Breathing

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Key result

Device-guided slow breathing lowers office SBP by ~15 mm Hg compared to home monitoring alone.

  • P<0.001
  • n=149

Why the study?

The effects of device-guided slow breathing on office systolic blood pressure in hypertensive outpatients were studied to assess potential blood pressure reduction.

Does a device to assist with slow breathing reduce office systolic blood pressure in hypertensive outpatients?

Population

149 untrained hypertensive outpatients, 50% male, age 59+/-10 years, baseline BP 150+/-9/86+/-9 mm Hg

Comparison

Device to guide slow breathing plus home BP monitor and instructions vs home BP monitor and instructions only

Design

Randomized controlled trial at five centers

Follow-up

8 weeks

Authors

WEW.J. ElliottGeneral / Preventive / LipidsJIJoseph L. IzzoGeneral / Preventive / LipidsWilliam B. WhiteWilliam B. WhiteGeneral / Preventive / Lipids

Discussion

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Implication

High device users (>180 min/8 wk) achieved larger office SBP reductions than low users or home monitoring alone; extends evidence for slow breathing as adjunct while underscoring adherence needs.

Study Design

Type

RCT (n=149)

Multicenter

Yes

Structured PICO

Does a device to assist with slow breathing reduce office systolic blood pressure in hypertensive outpatients?

P
Population
149 untrained hypertensive outpatients (mean age 59, 50% female, 77% on drug therapy) followed for 8 weeks.
I
Intervention
Device to guide slow breathing, provided alongside a home blood pressure monitor and simple written instructions, used over 8 weeks.
C
Comparator
Home blood pressure monitor and simple written instructions only.
O
Outcome
Change in office systolic blood pressure (SBP) over 8 weeks.surrogate

Main Result

Absolute Event Rate: -15% vs -9.2%

p-value: p=<0.001

Device-guided slow breathing significantly lowers office systolic blood pressure in hypertensive patients when accumulated use exceeds 180 minutes over 8 weeks.

Cite This Study

Elliott et al. (2004) conducted an RCT in Hypertension (n=149). Device to guide slow breathing vs. Home blood pressure monitor was evaluated on Change in office systolic blood pressure (p=<0.001). Device-guided slow breathing significantly lowered office SBP compared to home monitoring alone when total breathing time exceeded 180 minutes over 8 weeks (-15.0 vs -9.2 mm Hg; P<0.001 for trend).

synapsesocial.com/papers/6ab0ebfdfd65defcfcff6c3chttps://doi.org/10.1111/j.1524-6175.2004.03553.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Slow breathing reduces chemoreflex response to hypoxia and hypercapnia, and increases baroreflex sensitivity2001 · 244 citations
  2. 2Controlled breathing protocols probe human autonomic cardiovascular rhythms1998 · 157 citations
  3. 3Importance of Systolic Blood Pressure in Older Americans2000 · 403 citations
  4. 4Device-guided breathing exercises reduce blood pressure: ambulatory and home measurements2001 · 89 citations
  5. 5Effect of respiratory rate on the relationships between RR interval and systolic blood pressure fluctuations: a frequency-dependent phenomenon1998 · 148 citations