Key result
Chemotherapy plus radical resection achieves disease-free survival at 24 months in metastatic cardiac osteosarcoma.
Why the study?
Primary spinal osteosarcoma with rare metastatic heart lesions is associated with poor prognosis, and combined treatment including radical surgery may improve outcomes.
Case Report (n=1)
A multidisciplinary approach combining chemotherapy and radical surgery can yield favorable outcomes in patients with primary spinal osteosarcoma and rare metastatic heart lesions.
Solitary cardiac metastasis from spinal osteosarcoma may warrant resection after chemotherapy; this case extends sparse reports but leaves optimal management open.
Introduction. Primary spinal osteosarcoma and rare metastatic heart lesion are considered significant factors for poor prognosis. The available work indicates that combined treatment, including the radical surgery of heart solitary metastatic lesion, probably provides the best outcome.Case report. Man, 27-year-old, with Th8 spinal osteosarcoma and solitary left atrial metastasis. From October 2019 to February 2020 5 cycles of chemotherapy (high doses of platinum and doxorubicin) were carried out with positive effect. Next steps were surgery: March 2020 – spondylectomy of the Th8 vertebra with combined stabilization; September 2020 – subtotal resection with plasty of the right atrium, tricuspid valve and prosthesis of the right coronary artery. Between the first and second surgery, 4 more same chemotherapy cycles were carried out. Currently, 24 months after completion of treatment, there are no signs of the disease.Conclusion. The article presents a unique case of treatment of primary osteosarcoma and metastatic lesion of rare location. Multidisciplinary approach and combination treatment in specialized centers increase the probability of favorable outcome in such cases.
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Tararykova et al. (2023) conducted a case report in Th8 spinal osteosarcoma and solitary left atrial metastasis (n=1). Multidisciplinary approach (chemotherapy and radical surgery) was evaluated on Disease status. A multidisciplinary approach combining chemotherapy and radical surgery in a 27-year-old man with spinal osteosarcoma and heart metastasis resulted in no signs of disease at 24 months post-treatment.
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