Key result
QFR-based functional SYNTAX score linked to ~5% higher 2-year MACE risk per point.
Why the study?
The impact of quantitative flow ratio based functional SYNTAX score on prognostication and revascularization strategy choice in left main or multivessel coronary artery disease has not been fully investigated and requires further validation.
Does a QFR-based functional SYNTAX score improve risk classification and prognostication compared to standard anatomic SYNTAX score in patients with left main or multivessel coronary artery disease?
Population
607 patients with left main or multivessel coronary artery disease from the PANDA III trial
Comparison
QFR based functional SYNTAX score vs anatomic SYNTAX score
Design
Retrospective cohort analysis
Follow-up
2 years
Authors
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May aid prognostication in left main/multivessel CAD; leaves open prospective validation versus anatomic SYNTAX score.
Cohort (n=607)
Does a QFR-based functional SYNTAX score improve risk classification and prognostication compared to standard anatomic SYNTAX score in patients with left main or multivessel coronary artery disease?
Hazard Ratio: 1.05 (95% CI 1.02–1.07)
p-value: p=0.0001
A QFR-based functional SYNTAX score modestly improves risk discrimination and revascularization strategy selection compared to standard anatomic SYNTAX score in patients with complex coronary artery disease.
Zhang et al. (2020) conducted a cohort in Left main or multivessel coronary artery disease (n=607). Quantitative flow ratio (QFR) based functional SYNTAX score (FSS QFR) vs. Anatomic SYNTAX score (SS) was evaluated on 2-year major adverse cardiac events (a composite of cardiac death, any myocardial infarction, or ischemia-driven revascularization) (adjusted HR 1.05, 95% CI 1.02-1.07, p=0.0001). The quantitative flow ratio based functional SYNTAX score was an independent predictor of 2-year major adverse cardiac events (adjusted HR 1.05; 95% CI 1.02-1.07; P=0.0001).
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