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December 19, 2025Pleura and PeritoneumOpen Access

Changes in the immune tumor microenvironment of peritoneal mesothelioma under intraperitoneal chemotherapy

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Authors

HWHannah L. WilliamsACArianna CastagnaNBNazim Benzerdjeb

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Overview

Pilot study reveals sequential immune microenvironment remodeling in peritoneal mesothelioma under intraperitoneal chemotherapy, suggesting dynamic tumor evasion mechanisms.

Key Points

  • To evaluate sequential changes and immune cell dynamics within the tumor microenvironment of epithelioid peritoneal mesothelioma during intraperitoneal chemotherapy.
  • Analyzed archival peritoneal biopsies from 3 patients with epithelioid peritoneal mesothelioma treated with intraperitoneal chemotherapy across 19 sequential time points.
  • Performed digital image analysis on 140 immunohistochemistry sections and 20 histology sections across 1,120 measurement areas, assessing seven immune markers including CD4, CD8, CD68, and CD163 in tumor and peritumoral compartments.
  • Key T-cell markers CD4 and CD8 showed synchronized trends between tumor and peritumoral tissue, with early shifts indicating cell migration away from the tumor core.
  • Macrophage markers CD68 and CD163 demonstrated patient-specific infiltration profiles throughout treatment cycles.
  • Elevated immune marker levels in the microenvironment correlated negatively with overall survival.

Cite This Study

Williams et al. (2025) studied this question.

synapsesocial.com/papers/6ab1d58ee9cbf4e7a0eab046https://doi.org/10.1515/pp-2025-0021
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Also Consider

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  1. 1Real-world outcomes and molecular correlates of incorporating immunotherapy (IO) and bevacizumab (Bev) in treating patients with peritoneal mesothelioma (PeM): A comparative analysis with pleural mesothelioma (PM).2024
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  3. 3Spatial landscape of malignant pleural and peritoneal mesothelioma tumor immune microenvironment2024 · 9 citations
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