Key result
Unilateral adrenalectomy yields prolonged remission of primary hyperaldosteronism despite non-lateralized aldosterone secretion.
Why the study?
Primary hyperaldosteronism requires identification of subtypes with and without lateralization of aldosterone secretion for appropriate management.
Unilateral adrenalectomy may lead to prolonged remission in select patients with primary hyperaldosteronism even without lateralization of aldosterone secretion.
Answers are grounded in this paper and cite their sources.
May support surgery without lateralization in select cases; leaves open need for prospective trials before practice change.
Primary hyperaldosteronism can have different morphological substrates, however from a practical standpoint the most important is to identify two of its variants (subtypes)with and without lateralization of aldosterone secretion.
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Shustov et al. (2026) studied this question. Unilateral adrenalectomy achieved prolonged remission of primary hyperaldosteronism in a patient without lateralization of aldosterone secretion.
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