Key result
Male gender with elevated blood pressure links to lower hs-CRP and IL-1Ra despite similar MetS prevalence.
Why the study?
There are gender differences in inflammatory markers and their relationship with metabolic syndrome in subjects with elevated blood pressure that require clarification.
Are there gender differences in inflammatory markers and their relationship with metabolic syndrome in subjects with elevated blood pressure?
Cross-Sectional (n=551)
Are there gender differences in inflammatory markers and their relationship with metabolic syndrome in subjects with elevated blood pressure?
Answers are grounded in this paper and cite their sources.
In subjects with elevated blood pressure, there are significant gender differences in inflammatory markers and the relationship between adiponectin and metabolic syndrome.
Fasting insulin, adiponectin, high-sensitivity C-reactive protein (hs-CRP), and interleukin-1 receptor antagonist (IL-1Ra) were determined in 278 men and 273 women with blood pressure > or = 130 and/or > or = 85 mmHg and/or with antihypertensive medication. Metabolic syndrome (MetS) with the National Cholesterol Education Program (NCEP) criteria was observed in 35% of men and 34% of women. Men with MetS had lower hs-CRP and IL-1Ra than women. The absolute gender difference in adiponectin was smaller and those in IL-1Ra and hs-CRP were greater in subjects with MetS compared to those without. After adjustment with body mass index the association between insulin and the odd's ratio (OR) for MetS remained significant in both genders, in females also the association between the OR for MetS and adiponectin. There are gender differences in subjects with elevated blood pressure and MetS with respect to inflammatory markers and the relationship between adiponectin levels and MetS.
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Ahonen et al. (2009) conducted a cross-sectional in Elevated blood pressure (n=551). Male gender vs. Female gender was evaluated on Metabolic syndrome (MetS) prevalence. Male gender in subjects with elevated blood pressure was associated with lower hs-CRP and IL-1Ra levels compared to females, despite similar metabolic syndrome prevalence (35% vs 34%).
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