Key result
Women with metabolic syndrome had significantly higher levels of hs-CRP (P<0.001) and IL-1Ra (P=0.0016 to 0.0028) than men with metabolic syndrome, whereas no gender differences existed without MetS.
Observational (n=923)
No
p-value: p=<0.001
Women with metabolic syndrome have significantly higher levels of inflammatory markers (hs-CRP and IL-1Ra) compared to men with metabolic syndrome, suggesting a greater role of low-grade inflammation in their cardiovascular risk.
Should not yet change MetS risk assessment; leaves open whether sex-specific inflammation predicts CV outcomes.
AIMS: We explored gender differences in the association of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra) and adiponectin with the metabolic syndrome (MetS) defined by the National Cholesterol Education Program (NCEP) and the International Diabetes Federation (IDF) criteria. METHODS: A population-based study of 923 middle-aged subjects in Pieksämäki, East Finland. RESULTS: The prevalence of the MetS according to the IDF and NCEP definitions was 38% and 34% in men (N = 405) and 34% and 27% in women (N = 497), respectively. hs-CRP and IL-1Ra levels were higher in subjects with the MetS compared with those without the MetS in both sexes (P < 0.001). The levels of hs-CRP (P < 0.001) and IL-1Ra (P = 0.0016 for NCEP criteria, P = 0.0028 for IDF criteria) were significantly higher in women with MetS than in men with MetS. In contrast, in subjects without MetS, no gender differences in the levels of hs-CRP or IL-1Ra were found. CONCLUSION: Women with MetS, defined by the IDF or NCEP criteria, had higher levels of hs-CRP and IL-1Ra than did men with MetS. Thus, low-grade inflammation may contribute to the high risk of cardiovascular disease in women with MetS.
No takes yet. Share an insight, caveat, or question.
Saltevo et al. (2008) conducted an observational in Metabolic syndrome (n=923). Female gender (in subjects with metabolic syndrome) vs. Male gender (in subjects with metabolic syndrome) was evaluated on hs-CRP and IL-1Ra levels (p=<0.001). Women with metabolic syndrome had significantly higher levels of hs-CRP (P<0.001) and IL-1Ra (P=0.0016 to 0.0028) than men with metabolic syndrome, whereas no gender differences existed without MetS.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: