Key result
Incomplete anterior circle of Willis linked to ~95% higher odds of carotid intraplaque hemorrhage.
Why the study?
The relationship between high-risk carotid plaque features and an incomplete circle of Willis was not well established.
Is an incomplete circle of Willis associated with high-risk carotid plaque features such as intraplaque hemorrhage?
Population
482 patients from the multicenter Chinese Atherosclerosis Risk Evaluation (CARE-II) study
Comparison
Incomplete circle of Willis vs complete circle of Willis
Design
Observational multicenter study with magnetic resonance imaging
Authors
Loading...
Should not change practice; hypothesis-generating for hemodynamic links to carotid plaque vulnerability.
Observational (n=482)
Yes
Is an incomplete circle of Willis associated with high-risk carotid plaque features such as intraplaque hemorrhage?
Odds Ratio: 1.945 (95% CI 1.139–3.321)
p-value: p=0.015
An incomplete anterior circle of Willis is independently associated with intraplaque hemorrhage in carotid atherosclerotic plaques, suggesting a link between intracranial hemodynamics and carotid plaque vulnerability.
Zhou et al. (2018) conducted an observational in Carotid vulnerable atherosclerotic plaques (n=482). Incomplete anterior circle of Willis vs. Complete anterior circle of Willis was evaluated on Carotid intraplaque hemorrhage (OR 1.945, 95% CI 1.139-3.321, p=0.015). An incomplete anterior circle of Willis was independently associated with carotid intraplaque hemorrhage (adjusted OR 1.945; 95% CI 1.139-3.321; P=0.015).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: