Key result
Oral pilsicainide matches disopyramide infusion for terminating recent-onset AF within two hours.
Why the study?
The effectiveness of a single oral dose of pilsicainide for terminating acute-onset AF had not been compared with infusion of other antiarrhythmic drugs.
Does a single oral dose of pilsicainide improve termination of atrial fibrillation within 2 hours compared to an infusion of disopyramide in patients with symptomatic paroxysmal atrial fibrillation?
Comparison
Single oral dose of pilsicainide vs infusion of disopyramide
Design
Multicenter randomized trial
Follow-up
2 hours
Authors
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Single-dose oral pilsicainide may facilitate convenient AF termination; leaves open comparative efficacy versus disopyramide infusion in larger cohorts.
RCT (n=72)
randomized
Yes
Does a single oral dose of pilsicainide improve termination of atrial fibrillation within 2 hours compared to an infusion of disopyramide in patients with symptomatic paroxysmal atrial fibrillation?
Absolute Event Rate: 73% vs 56%
p-value: p=NS
A single oral dose of pilsicainide is as effective as an intravenous infusion of disopyramide for terminating recent-onset paroxysmal atrial fibrillation.
Kumagai et al. (2000) conducted an RCT in Paroxysmal Atrial Fibrillation (n=72). Pilsicainide vs. Disopyramide 2 mg/kg (maximum dose = 100 mg) infusion was evaluated on Termination of AF within 2 hours of drug administration (p=NS). A single oral dose of pilsicainide was as effective as an infusion of disopyramide for terminating recent-onset atrial fibrillation within 2 hours (73% vs 56%, NS).
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