Key result
Morin hydrate abrogates doxorubicin-induced hepatorenal toxicity and histological lesions in rats.
Why the study?
Doxorubicin induces organ toxicities including hepatorenal damage, and the potential protective effect of morin hydrate against this toxicity was investigated.
Hypothesis-generating in rats; leaves open any role for morin in preventing doxorubicin toxicity in patients.
Objective: Doxorubicin (DOX) is a frontline antineoplastic drug that kills cancer cells through genotoxic mechanism; however, it induces organ toxicities. This study assayed whether morin hydrate (MOH) could abrogate DOX hepatorenal toxicity in rats. Materials and Methods: There were 4 groups of rats: Control, MOH, DOX and MOH + DOX. Rats were administered MOH (orally, 100 mg/kg bw) for 7 consecutive days, while DOX was injected (40 mg/kg, ip) on the 5th day only. Hepatorenal function markers, and glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities were estimated in both organs. Hepatorenal glutathione (GSH), malondialdehyde (MDA), and nitric oxide (NO) levels were estimated with histopathology. Results: DOX significantly (p<0.05) reduced antioxidant enzyme activities and GSH level, while NO and MDA levels increased (p<0.05) compared to the control. DOX prominently altered hepatorenal indices and induced histopathological alterations. MOH abrogated the DOX hepatorenal toxicity and alleviated the histological lesions in the liver and kidney. Conclusion: MOH restored the indices via antioxidant mechanism and downregulation of NO overproduction in rats.
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Famurewa et al. (2023) studied Doxorubicin-induced hepatorenal toxicity. Morin hydrate (MOH) vs. Doxorubicin alone was evaluated on Hepatorenal function markers, antioxidant enzyme activities, and oxidative stress levels (GSH, MDA, NO). Morin hydrate abrogated doxorubicin-induced hepatorenal toxicity and alleviated histological lesions in the liver and kidney of rats.
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