Key result
Parental death from CAD is linked to ~30% higher CAD risk, especially for early-onset disease.
Why the study?
The independent risk associated with parental history of coronary artery disease death before or after age 65 for early or late onset CAD in offspring was unclear.
Does a parental history of death by coronary artery disease increase the risk of early or late onset CAD in offspring?
Cohort (n=5,209)
Does a parental history of death by coronary artery disease increase the risk of early or late onset CAD in offspring?
Parental history of CAD death is an independent risk factor for CAD in offspring, with a stronger effect for early-onset CAD, and is not mediated by other shared risk factors.
Answers are grounded in this paper and cite their sources.
Parental CAD death history may flag higher-risk offspring; leaves open its incremental value for risk stratification beyond traditional factors.
Data from the Framingham Study, a population-based prospective study of 5,209 persons, were analyzed to determine whether a parental history of death by coronary artery disease (CAD) before or after 65 years of age was an independent risk factor for CAD of early onset (age younger than 60 years) or late onset (age 60 years or older) among the men and women in the cohort. Death due to CAD in parents was associated with a 30% increase in the risk of CAD. The effect was apparently stronger for an early CAD outcome, with adjusted relative risks of 1.5 for early and 1.2 for late outcome CAD. The effect of parental CAD death on risk was not mediated by other shared risk factors for CAD. These findings were similar for those with either a mother or a father with CAD, if CAD onset in the offspring occurred before the age of 60 years. For persons with CAD at age 60 years or older, maternal CAD death was a stronger predictor of CAD than paternal CAD death. The association with parental history of CAD was similar among men and women in the cohort, with adjusted relative risks of 1.3 and 1.2, respectively. However, early age of parental CAD death may account for the association among women (RR = 1.6), whereas late age of CAD death for either parent was associated with the risk of CAD among men (RR = 1.4).
No takes yet. Share an insight, caveat, or question.
Schildkraut et al. (1989) conducted a cohort in Coronary artery disease (n=5,209). Parental history of death by coronary artery disease vs. No parental history of CAD death was evaluated on Coronary artery disease (CAD) (RR 1.3). Parental death due to coronary artery disease was associated with a 30% increased risk of CAD, with a stronger association for early-onset CAD.
Synapse has enriched 10 related papers. Consider them for comparative context: