Key result
Both maternal and paternal history of MI increased the risk of CVD in men (RR 1.85) and women (RR 2.05), with early parental MI (<60 years) conferring a greater risk than MI at older ages.
Why the study?
Does maternal and paternal history of MI increase the risk of cardiovascular disease in men and women?
Cohort (n=61,947)
Does maternal and paternal history of MI increase the risk of cardiovascular disease in men and women?
Relative Risk: 1.85
Early parental history of MI (<60 years) significantly increases CVD risk in both men and women, though any maternal history of MI may also be an important risk factor.
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Early parental MI history may refine primary prevention risk assessment; supports incorporating family history into models but leaves practice change open.
Sesso et al. (2001) conducted a cohort in Cardiovascular disease (n=61,947). Maternal and paternal history of myocardial infarction vs. No parental history of MI was evaluated on Cardiovascular disease (CVD) (RR 1.85). Both maternal and paternal history of MI increased the risk of CVD in men (RR 1.85) and women (RR 2.05), with early parental MI (<60 years) conferring a greater risk than MI at older ages.
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