Paternal and Maternal History of Myocardial Infarction and Cardiovascular Diseases Incidence in a Dutch Cohort of Middle-Aged Persons
View Full Paper
Ask AI
Bookmark
Share
Why the study?
Does a parental history of myocardial infarction increase the incidence of cardiovascular diseases in middle-aged adults?
Structured PICO
Does a parental history of myocardial infarction increase the incidence of cardiovascular diseases in middle-aged adults?
P
Population
10,524 adults aged 40-65 years (4,878 men, 5,646 women) from the Dutch MORGEN cohort (Amsterdam, Maastricht, Doetinchem).
I
Intervention
Parental history of myocardial infarction (paternal, maternal, or both), including age of onset.
C
Comparator
Both parents without a history of myocardial infarction.
O
Outcome
First cardiovascular disease event (fatal or non-fatal) during 10-year follow-up.composite
A maternal history of MI before age 60 is a particularly strong predictor of cardiovascular disease incidence, especially in women, highlighting the importance of detailed family history in risk stratification.
Limitations
- Parental history of MI was based on self-report by the respondents.
- Some parents were too young to have experienced an MI, especially mothers.
- Minor underestimation and misclassification of non-fatal and fatal endpoints from registries.
Authors
Discussion
No takes yet. Share an insight, caveat, or question.
Implication
Parental MI history was associated with higher CVD incidence; leaves open whether it improves risk stratification beyond standard factors.
Cite This Study
Dis et al. (2011) studied this question.
View Full Paper
Ask AI
Bookmark
Share