Key result
Long-term antiangiogenic tyrosine kinase inhibitors linked to fatal Stanford type A aortic dissection.
Why the study?
Acute aortic dissection as a potential adverse event associated with long-term use of antiangiogenic tyrosine kinase inhibitors is not well characterized.
Comparison
Long-term use of multiple antiangiogenic tyrosine kinase inhibitors
Design
Case report
Follow-up
Approximately 5 years
Authors
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Alerts to possible aortic dissection risk on sunitinib in RCC; leaves open class effect versus prior TKI exposure.
Case Report (n=1)
Long-term use of antiangiogenic tyrosine kinase inhibitors may be associated with the rare but fatal adverse event of acute aortic dissection.
Funahashi et al. (2014) conducted a case report in Metastatic clear cell renal cell carcinoma (n=1). Tyrosine kinase inhibitors (pazopanib, lapatinib, sunitinib) was evaluated on Acute aortic dissection. Long-term use of antiangiogenic tyrosine kinase inhibitors over 5 years was associated with a fatal Stanford type A acute aortic dissection in a 48-year-old male.
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