February 1, 2018Open Access
Comparison of in-hospital outcomes between octogenarians and nonagenarians undergoing transcatheter aortic valve replacement: a propensity matched analysis.
Key result
TAVR in nonagenarians is linked to slightly higher in-hospital mortality than in octogenarians.
- P≤0.001
Why the study?
In-hospital outcome differences and mortality predictors between octogenarians and nonagenarians undergoing TAVR for severe AS were not well characterized.
Does TAVR in nonagenarians compared to octogenarians result in different in-hospital mortality and complications?
Population
Patients aged 80 years and older undergoing TAVR for severe AS from the National Inpatient Sample 2012-2014
Design
Propensity score matched cohort study
Follow-up
In-hospital
Authors
Discussion
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Overview
Nonagenarians face higher in-hospital risks after TAVR; leaves open whether age thresholds should refine shared decision-making or trial eligibility.
Study Design
Type
Cohort
Multicenter
Yes
Structured PICO
Does TAVR in nonagenarians compared to octogenarians result in different in-hospital mortality and complications?
P
Population
Octogenarians and nonagenarians undergoing transcatheter aortic valve replacement for severe aortic stenosis, assessed for in-hospital outcomes.
E
Exposure
Transcatheter aortic valve replacement (TAVR) in nonagenarians (age ≥90)
C
Comparator
Transcatheter aortic valve replacement (TAVR) in octogenarians (age 80-89) (1:2 propensity matched)
O
Outcome
In-hospital mortalityhard clinical
Main Result
p-value: p=≤ 0.001
In-hospital mortality after TAVR is slightly higher in nonagenarians compared to octogenarians, partly due to higher complication rates, but remains acceptable.
Cite This Study
Doshi et al. (2018) conducted a cohort in Severe aortic valve stenosis. Nonagenarian age vs. Octogenarian age was evaluated on In-hospital mortality (p=≤ 0.001). In-hospital mortality was slightly higher in nonagenarians compared to octogenarians undergoing TAVR (P≤0.001), which was partly explained by higher complication rates.