Why the study?
The pathophysiology of allograft heart valve failure, including the role of cryopreservation-induced damage and immunogenicity, is not fully understood.
Does an ice-free vitrification method of cryopreservation reduce calcification of allogeneic heart valves compared to standard freezing in a rat implant model?
Does an ice-free vitrification method of cryopreservation reduce calcification of allogeneic heart valves compared to standard freezing in a rat implant model?
p-value: p=<0.01
Ice-free vitrification cryopreservation reduces allogeneic heart valve calcification in a rat model compared to standard freezing methods, suggesting a potential strategy to improve in vivo performance of cryopreserved allogeneic heart valves.
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Brockbank et al. (2003) studied Bioprosthetic heart valve calcification. Ice-free, vitrification method of cryopreservation vs. Standard commercial heart valve freezing method and fresh controls was evaluated on Calcium concentration in explants (p=<0.01).
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