Key result
Tp-Te/QT ratio predicts sepsis mortality with an AUC of ~0.81 and identifies higher arrhythmia risk.
Why the study?
About 50% of sepsis patients develop sepsis-induced myocardial dysfunction which increases mortality, and the prognostic value of Tp-Te and Tp-Te/QT in sepsis is unclear.
Do Tp-Te interval and Tp-Te/QT ratio predict death in patients with sepsis?
Population
625 participants including 201 sepsis patients, 213 heart failure patients, and 211 healthy participants
Comparison
Sepsis patients vs heart failure patients vs healthy participants; septic shock vs sepsis without shock; death vs survival in sepsis
Design
Observational cohort study
Authors
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May support ECG risk stratification in sepsis; hypothesis-generating and requires prospective validation before practice change.
Observational (n=625)
No
Do Tp-Te interval and Tp-Te/QT ratio predict death in patients with sepsis?
Effect estimate: AUC 0.808
p-value: p=<0.001
Tp-Te interval and Tp-Te/QT ratio are valuable electrocardiographic markers for predicting disease severity and mortality in patients with sepsis.
Li et al. (2022) conducted an observational in Sepsis (n=625). Tp-Te interval and Tp-Te/QT ratio vs. Healthy controls and heart failure patients was evaluated on 28-day all-cause mortality (AUC 0.808, p=<0.001). The Tp-Te/QT ratio demonstrated strong predictive value for 28-day mortality in sepsis patients with an AUC of 0.808, and a cutoff of ≥0.32 identified patients at higher risk for arrhythmias.
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