Key result
Metabolic syndrome alone in AF is linked to ~52% higher risk of major cardiovascular events.
Why the study?
Whether non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular events independently from metabolic syndrome (MetS) in patients with atrial fibrillation was still debated.
Does the presence of metabolic syndrome or NAFLD increase the risk of cardiovascular events in patients with non-valvular atrial fibrillation?
Cohort (n=1,735)
Yes
Does the presence of metabolic syndrome or NAFLD increase the risk of cardiovascular events in patients with non-valvular atrial fibrillation?
Hazard Ratio: 1.517 (95% CI 1.01–2.28)
Absolute Event Rate: 4.58% vs 2.92%
p-value: p=0.045
In patients with non-valvular atrial fibrillation, metabolic syndrome increases the risk of cardiovascular events, whereas NAFLD alone does not appear to increase this risk.
No takes yet. Share an insight, caveat, or question.
MetS was associated with higher CVE risk in AF; leaves open independent NAFLD contribution and needs prospective confirmation.
Pastori et al. (2021) conducted a cohort in non-valvular atrial fibrillation (n=1,735). Metabolic syndrome vs. Absence of metabolic syndrome and NAFLD was evaluated on Composite of fatal/non-fatal myocardial infarction or ischemic stroke, transient ischemic attack (TIA) and cardiovascular death (HR 1.517, 95% CI 1.010-2.280, p=0.045). In patients with atrial fibrillation, the presence of metabolic syndrome alone significantly increased the risk of cardiovascular events compared to those without metabolic syndrome or NAFLD (HR 1.517).
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