Key result
ANF reduces glucose-induced plasma insulin increases by ~40% in mice.
Why the study?
The effects of atrial natriuretic factor on basal and stimulated insulin and glucagon secretion in mice and rats were not fully understood.
Population
Mice and rats
Comparison
Synthetic rat ANF-(1-28) injection vs control with glucose or carbachol
Design
Preclinical experimental study
Authors
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ANF does not alter basal insulin or glucagon in rodents; leaves open effects on stimulated secretion and human relevance.
Effect estimate: 40% inhibition
Absolute Event Rate: 81% vs 114%
p-value: p=<0.01
Atrial natriuretic factor (ANF) inhibits glucose-stimulated insulin secretion in mice and rats, suggesting it may act as a modulator of insulin secretion.
Bo Åhrén (1988) studied this question. synthetic rat ANF-(1-28) vs. controls was evaluated on plasma insulin levels after glucose injection in mice (40% inhibition, p=<0.01). In mice, ANF injected with glucose inhibited the increase in plasma insulin levels by 40% compared to controls (81 vs 114 microU/ml; P<0.01).
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