Key result
Tirofiban linked to profound thrombocytopenia during stent-assisted embolization for ruptured intracranial aneurysm.
Why the study?
Tirofiban hydrochloride can induce profound thrombocytopenia during intracranial aneurysm stent-assisted coiling, but detailed clinical reports are limited.
Case Report (n=1)
No
Tirofiban administration during neurointerventional procedures can cause severe, reversible thrombocytopenia.
Answers are grounded in this paper and cite their sources.
Alerts clinicians to monitor platelets with tirofiban in neurointerventions; leaves open true incidence and risk factors.
1例左侧后交通动脉瘤破裂伴蛛网膜下腔出血患者急诊行全脑血管造影术 + 颅内动脉瘤支架辅助栓塞术术中予盐酸替罗非班后出现极重度血小板减少症，最低血小板计数为1 × 109/L。在停用该药后及对症治疗后血小板逐渐恢复，继续予以阿司匹林肠溶片、硫酸氢氯吡格雷预防血栓，最终好转出院。A patient with a ruptured left posterior communicating artery aneurysm accompanied by subarachnoid hemorrhage underwent emergency cerebral angiography and intracranial aneurysm stent-assisted coiling. During the procedure, administration of tirofiban hydrochloride induced profound thrombocytopenia, with the lowest platelet count dropping to 1 × 109/L. Following discontinuation of the medication and symptomatic treatment, platelet levels gradually recovered. Thrombosis prophylaxis was maintained with enteric-coated aspirin tablets and clopidogrel bisulfate. The patient ultimately improved and was discharged.
No takes yet. Share an insight, caveat, or question.
光文 周 (2025) conducted a case report in Ruptured left posterior communicating artery aneurysm with subarachnoid hemorrhage (n=1). Tirofiban was evaluated on Development of profound thrombocytopenia. Administration of tirofiban during stent-assisted embolization for a ruptured intracranial aneurysm induced profound thrombocytopenia, with platelet counts dropping to 1 × 10^9/L before recovering upon drug discontinuation.
Synapse has enriched 10 related papers. Consider them for comparative context: